Colorectal Cancer Trial Landscape (May 2026)

Last updated: May 14, 2026 · Built by a patient who got tired of scrolling ClinicalTrials.gov

Overview

1,391
Recruiting
248
Phase 1
567
Phase 2
165
Phase 3
21
Phase 4

Active interventional trials with status RECRUITING or NOT_YET_RECRUITING. A multi-phase trial (e.g. 1/2) is counted in each of its phases.

Mechanism Breakdown

Recruiting trials grouped by drug class. Trials with unclassifiable or non-therapeutic interventions are excluded from this view.

Checkpoint inhibitor
189
Chemotherapy
145
Other / unclassified
67
Monoclonal antibody
65
Bispecific antibody
47
Tyrosine kinase inhibitor (TKI)
27
Antibody-drug conjugate (ADC)
23
CAR-T cellular therapy
21
Other inhibitor
17
Small-molecule inhibitor
16
Vaccine (other)
12
Kinase inhibitor (other)
12

Recently Updated Trials

NCTPhaseTitleMechanism
NCT04824053Effects of UNICLA-A2 Dairy Products on Patients at High-risk of Colorectal Cancer DevelopmentUnknown mechanism
NCT056725242A Study of Tucatinib and Trastuzumab in People With Rectal CancerHER2 -- monoclonal antibody + HER2 -- tyrosine kinase inhibitor
NCT074165521A Study to Investigate CEA-PRIT 2.0 in Participants With Metastatic Colorectal Cancer (mCRC)CEA -- pretargeted radioimmunotherapy (PRIT)
NCT07229443CoGENES Randomized Controlled Trial (RCT)Unknown mechanism
NCT061231563Interest of Early Erectile Rehabilitation With Sildenafil After Radiotherapy and Proctectomy for Rectal CancerPhosphodiesterase 5 (PDE5) -- PDE5 inhibitor (Sildenafil)

Top Sponsors

SponsorRecruiting trials
Fudan University69
Sun Yat-sen University49
Sixth Affiliated Hospital, Sun Yat-sen University26
M.D. Anderson Cancer Center17
Second Affiliated Hospital, School of Medicine, Zhejiang University15

Geographic Distribution

Countries/regions with the most active trial sites for colorectal cancer. A multi-site trial is counted once per country/region.

China
477
United States
327
France
95
Italy
72
Canada
65
Spain
61
Germany
57
Netherlands
41
South Korea
40
Belgium
36

Emerging Classes

Phase-1 trials whose listed start date falls within the last 12 months — the leading edge of the field.

StartNCTTitleMechanism
Sep 3, 2026NCT07500298Phase 1 Study Of SAR445877 In Combination With FOLFOX6 And Bevacizumab As First-Line Treatment For Microsatellite Stable Metastatic Colorectal CancerFcγRIIb -- monoclonal antibody (SAR445877) plus chemotherapy and anti-VEGF antibody
Sep 2026NCT07545122A Phase 1a/1b, First-Time-in-Human Study of CT-202, a Nectin-4 Directed Bispecific Antibody, in Participants With Recurring Triple Negative Breast, Colorectal, Urothelial CancersNectin-4 -- bispecific antibody (CT-202)
Jul 21, 2026NCT07363408Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal CancerPD-1 + unknown target (Ivonescimab, ADG126) -- immune checkpoint blockade + bispecific antibody
Jun 30, 2026NCT07543471A Phase I Multicentre Randomized Double-Blind Parallel-Controlled Study of HLX05-N vs. ERBITUX® in Metastatic Colorectal CancerEGFR -- monoclonal antibody (cetuximab)
Jun 10, 2026NCT07318389ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal CancerVEGF + EGFR + chemotherapy -- targeted antibodies (Bevacizumab, Cetuximab, Panitumumab) plus chemotherapy (FOLFIRI)
Jun 1, 2026NCT07277322Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver MetastasesIL-4Rα -- monoclonal antibody (Dupilumab); PD-1 -- immune checkpoint inhibitor (Toripalimab)
Jun 2026NCT07128355Botensilimab, Balstilimab, and SBRT in Colorectal CancerCTLA-4 + PD-1 -- immune checkpoint inhibitors + radiation therapy
May 12, 2026NCT07416552A Study to Investigate CEA-PRIT 2.0 in Participants With Metastatic Colorectal Cancer (mCRC)CEA -- pretargeted radioimmunotherapy (PRIT)

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Source: ClinicalTrials.gov, synced daily. Aggregated by ClinTrialFinder.